Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Factor VIII genotype and inhibitor development in patients with haemophilia A: highest risk in patients with splice site mutations.

Haemophilia : the official journal of the World Federation of Hemophilia - 1 Jul 2008

Boekhorst J, Lari G R, D'Oiron R, Costa J M, Nováková I R O, Ala F A, Lavergne J M, VAN Heerde W L

Abstract excerpt

The appearance of inhibitory antibodies against factor VIII (FVIII) is the most severe and costly complication of replacement therapy in patients with haemophilia A (HA). To determine the relationship between FVIII genotype and inhibitor development, baseline FVIII activity, genotype and inhibito...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autoantibodies
Share to Cohort Studies
Share to DNA Mutational Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Factor VIII

Share to Genetic Predisposition to Disease

Share to Genotype

Share to Hemophilia A

Share to RNA Splice Sites

Source

Identifiers

PMID: 18503540
DOI: 10.1111/j.1365-2516.2008.01694.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18503540-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Factor VIII genotype and inhibitor development in patients with haemophilia A: highest risk in patients with splice site mutations.PMID 18503540Read ↗

Factor VIII (FVIII) gene mutations in 120 patients with hemophilia A: detection of 26 novel mutations and correlation with FVIII inhibitor development.Semantic proximity Read ↗

F8 gene mutation type and inhibitor development in patients with severe hemophilia A: systematic review and meta-analysis.Semantic proximity Read ↗

Relationship between mutations in severe hemophilia A and risk of inhibitor development: A large single-center study.Semantic proximity Read ↗

The molecular basis of hemophilia A: genotype-phenotype relationships and inhibitor development.Semantic proximity Read ↗

Influence of the type of F8 gene mutation on inhibitor development in a single centre cohort of severe haemophilia A patients.Semantic proximity Read ↗

Genetic risk factors for inhibitors in haemophilia A.Semantic proximity Read ↗

Spectrum of F8 Genotype and Genetic Impact on Inhibitor Development in Patients with Hemophilia A from Multicenter Cohort Studies (J-HIS) in Japan.Semantic proximity Read ↗

Factor VIII genotype characterization of haemophilia A affected patients with transient and permanent inhibitors: a comprehensive Argentine study of inhibitor risks.Semantic proximity Read ↗

Prediction of factor VIII inhibitor development in the SIPPET cohort by mutational analysis and factor VIII antigen measurement.Semantic proximity Read ↗

The incidence of inhibitor development according to specific mutations--and treatment?Semantic proximity Read ↗

Race, ethnicity, F8 variants, and inhibitor risk: analysis of the "My Life Our Future" hemophilia A database.Semantic proximity Read ↗

The Italian AICE-Genetics hemophilia A database: results and correlation with clinical phenotype.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.