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Article

Factor VIII genotype and inhibitor development in patients with haemophilia A: highest risk in patients with splice site mutations.

Haemophilia : the official journal of the World Federation of Hemophilia - 1 Jul 2008

Boekhorst J, Lari G R, D'Oiron R, Costa J M, Nováková I R O, Ala F A, Lavergne J M, VAN Heerde W L

Abstract excerpt

The appearance of inhibitory antibodies against factor VIII (FVIII) is the most severe and costly complication of replacement therapy in patients with haemophilia A (HA). To determine the relationship between FVIII genotype and inhibitor development, baseline FVIII activity, genotype and inhibitor development were reviewed in 1104 patients with HA. In patients with severe HA, splicing errors present the highest...

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Identifiers

PMID: 18503540
DOI: 10.1111/j.1365-2516.2008.01694.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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