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Spectrum of F8 Genotype and Genetic Impact on Inhibitor Development in Patients with Hemophilia A from Multicenter Cohort Studies (J-HIS) in Japan.

Thrombosis and haemostasis - 1 May 2021

Shinozawa Keiko, Yada Koji, Kojima Tetsuhito, Nogami Keiji, Taki Masashi, Fukutake Katsuyuki, Yoshioka Akira, Shirahata Akira, Shima Midori

Abstract excerpt

Some genetic and treatment-related factors are risk factors for inhibitor development in patients with hemophilia A (PwHA). However, the genotype distribution of the factor VIII gene (F8) and genetic impact on inhibitor development in Japanese PwHA remain unknown. In 2007, the Japan Hemophilia Inhibitor Study 2 (J-HIS2) was organized to establish a nationwide registry system for hemophiliacs and to elucidate risk...

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PMID: 33254277
DOI: 10.1055/s-0040-1721385

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