Article
Factor VIII genotype characterization of haemophilia A affected patients with transient and permanent inhibitors: a comprehensive Argentine study of inhibitor risks.
Haemophilia : the official journal of the World Federation of Hemophilia - 1 Jul 2013
Rossetti L C, Szurkalo I, Radic C P, Abelleyro M M, Primiani L, Neme D, Candela M, Bianco R P, de Tezanos Pinto M, Larripa I B, De Brasi C D
Abstract excerpt
Inhibitor development against exogenous factor VIII is a severe impairment of replacement therapy affecting 18% of Argentine patients with severe haemophilia A (HA). To study the molecular predisposition for inhibitor development, we genotyped 260 HA patients with and without inhibitors, countrywide. The inhibitor-positive population (19 transients, 15 low responders, LR and 70 high responders, HR) of 104...
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