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Article

Relationship between mutations in severe hemophilia A and risk of inhibitor development: A large single-center study.

Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis - 1 Dec 2024

Moghadam Arash Ahmadfard, Manafzadeh Amir Reza, Nikoonia M R, Moazezi Seyedeh Somayeh, Nekoei Khadijeh Dajliry, Ramezan Farahnaz, Bashash Davood, Hamidpour Mohsen, Tabibian Shadi

Abstract excerpt

BACKGROUND: One of the major problems for patients with severe hemophilia A (HA) is the development of neutralizing antibodies against factor VIII. This study aimed to analyze the molecular and clinical profiles of patients with severe HA and to determine if certain genetic variants predispose to inhibitor development in these patients. METHODS: A single-center study was conducted among patients with severe HA...

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PMID: 39276593
DOI: 10.1016/j.transci.2024.104002

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