Article
The molecular basis of hemophilia A: genotype-phenotype relationships and inhibitor development.
Seminars in thrombosis and hemostasis - 1 Feb 2003
Goodeve Anne C, Peake Ian R
Abstract excerpt
The molecular basis of hemophilia A has been extensively studied over the last two decades, and this analysis of the factor VIII (FVIII) gene has rendered it one of the most studied of all human genes. A wide range of different mutation types has been identified that includes the novel intrachromosomal inversions involving regions in introns 1 and 22 of the FVIII gene as well as many mutation types found in other...
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