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Article

Palm mutants in DNA polymerases alpha and eta alter DNA replication fidelity and translesion activity.

Molecular and cellular biology - 1 Apr 2004

Niimi Atsuko, Limsirichaikul Siripan, Yoshida Shonen, Iwai Shigenori, Masutani Chikahide, Hanaoka Fumio, Kool Eric T, Nishiyama Yukihiro, Suzuki Motoshi

Abstract excerpt

We isolated active mutants in Saccharomyces cerevisiae DNA polymerase alpha that were associated with a defect in error discrimination. Among them, L868F DNA polymerase alpha has a spontaneous error frequency of 3 in 100 nucleotides and 570-fold lower replication fidelity than wild-type (WT) poly...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15024063
DOI: 10.1128/MCB.24.7.2734-2746.2004
PMCID: PMC371111

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15024063-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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