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Article

Biochemical analysis of active site mutations of human polymerase η.

Mutation research - 1 Jan 2000

Suarez Samuel C, Beardslee Renee A, Toffton Shannon M, McCulloch Scott D

Abstract excerpt

DNA polymerase η (pol η) plays a critical role in suppressing mutations caused by the bypass of cis-syn cyclobutane pyrimidine dimers (CPD) that escape repair. There is evidence this is also the case for the oxidative lesion 7,8-dihydro-8-oxo-guanine (8-oxoG). Both of these lesions cause moderate to severe blockage of synthesis when encountered by replicative polymerases, while pol η displays little no to pausing...

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Source

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Identifiers

PMID: 23499771
DOI: 10.1016/j.mrfmmm.2013.03.001
PMCID: PMC3669660

Genes

CPD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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