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Article

Influences of the N700S thrombospondin-1 polymorphism on protein structure and stability.

The Journal of biological chemistry - 18 Jul 2008

Carlson C Britt, Liu Yuanyuan, Keck James L, Mosher Deane F

Abstract excerpt

Thrombospondins (THBSs) are multimodular, secreted proteins characterized by a signature domain comprising a unique set of 13 calcium-binding repeats flanked by epidermal growth factor (EGF)-like and lectin-like modules. A polymorphism that changes a conserved Asn to Ser at residue 700 in the most N-terminal calcium-binding repeat of THBS-1 (repeat 1C) is found in 8-10% of European populations and has been linked...

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Identifiers

PMID: 18499674
DOI: 10.1074/jbc.M800223200
PMCID: PMC2459288

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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