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Article

Characterization of human cardiac calsequestrin and its deleterious mutants.

Journal of molecular biology - 2 Nov 2007

Kim Eunjung, Youn Buhyun, Kemper Lenord, Campbell Cait, Milting Hendrik, Varsanyi Magdolna, Kang ChulHee

Abstract excerpt

Mutations of conserved residues of human cardiac calsequestrin (hCSQ2), a high-capacity, low-affinity Ca2+-binding protein in the sarcoplasmic reticulum, have been associated with catecholamine-induced polymorphic ventricular tachycardia (CPVT). In order to understand the molecular mechanism and pathophysiological link between these CPVT-related missense mutations of hCSQ2 and the resulting arrhythmias, we...

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Share to Calcium
Share to Calsequestrin
Share to Circular Dichroism

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Protein Structure, Secondary

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Share to Spectrometry, Fluorescence

Share to Tachycardia, Ventricular

Source

Identifiers

PMID: 17881003
DOI: 10.1016/j.jmb.2007.08.055

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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