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Article

Structure of the calcium-rich signature domain of human thrombospondin-2.

Nature structural & molecular biology - 1 Oct 2005

Carlson C Britt, Bernstein Douglas A, Annis Douglas S, Misenheimer Tina M, Hannah Blue-leaf A, Mosher Deane F, Keck James L

Abstract excerpt

Thrombospondins (THBSs) are secreted glycoproteins that have key roles in interactions between cells and the extracellular matrix. Here, we describe the 2.6-A-resolution crystal structure of the glycosylated signature domain of human THBS2, which includes three epidermal growth factor-like modules, 13 aspartate-rich repeats and a lectin-like module. These elements interact extensively to form three structural...

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Source

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Identifiers

PMID: 16186819
DOI: 10.1038/nsmb997
PMCID: PMC2219892

Genes

THBS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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