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Article

Polymorphisms A387P in thrombospondin-4 and N700S in thrombospondin-1 perturb calcium binding sites.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Nov 2005

Stenina Olga I, Ustinov Valentin, Krukovets Irene, Marinic Tina, Topol Eric J, Plow Edward F

Abstract excerpt

Recent genetic studies have associated members of the thrombospondin (TSP) gene family with premature cardiovascular disease. The disease-associated polymorphisms lead to single amino acid changes in TSP-4 (A387P) and TSP-1 (N700S). These substitutions reside in adjacent domains of these highly homologous proteins. Secondary structural predictive programs and the homology of the domains harboring these amino acid...

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PMID: 16148025
DOI: 10.1096/fj.05-3712fje

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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