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Article

Mutations targeting intermodular interfaces or calcium binding destabilize the thrombospondin-2 signature domain.

The Journal of biological chemistry - 3 Oct 2008

Carlson C Britt, Gunderson Kristin A, Mosher Deane F

Abstract excerpt

Thrombospondins (THBSs) are a family of secreted calcium-binding glycoproteins with roles in angiogenesis, cell motility, apoptosis, cytoskeletal organization, and extracellular matrix organization. The THBS-2 signature domain (three epidermal growth factor (EGF)-like modules, a wire module with 13 calcium-binding repeats, and a lectin-like module) binds 30 calcium ions and forms extensive interactions among its...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18682400
DOI: 10.1074/jbc.M803842200
PMCID: PMC2555992

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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