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Article

Novel functional PI 3‐kinase antagonists inhibit cell growth and tumorigenicity in human cancer cell lines

1 Jun 2000

Abstract excerpt

New efforts in cancer therapy are being focused at various levels of signaling pathways. With phosphoinositide 3-kinase (PI3-K) potentially being necessary for a range of cancer-related functions, we have investigated the influence of selected inositol tris- to hexakisphosphates on cell growth and tumorigenicity. We show that micromolar concentrations of inositol 1,3,4,5,6-pentakisphosphate and inositol...

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Share to Coagulation, Bradykinin, Polyphosphates, and Angioedema
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PMID: 10834940
DOI: 10.1096/fasebj.14.9.1179

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