Article
Phosphatidylinositol 3-kinase translocation to the nucleus is an early event in the interleukin-1 signalling mechanism in human osteosarcoma Saos-2 cells.
Advances in enzyme regulation - 1 Jan 1999
Maraldi N M, Marmiroli S, Rizzoli R, Mazzotti G, Manzoli F A
Abstract excerpt
Interleukin 1 (IL-1) is a proinflammatory cytokine which can elicit proliferative, differentiative, or metabolic responses. The molecular mechanisms by which IL-1 signals are transduced from the plasma membrane to the nucleus, although extensively studied, have not been completely elucidated. We previously demonstrated that human osteosarcoma Saos-2 cells incubated with IL-1 presented a rapid and transient...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.