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Article

Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.

Journal of cellular physiology - 1 Jun 2021

Cidad Pilar, Alonso Esperanza, Arévalo-Martínez Marycarmen, Calvo Enrique, de la Fuente Miguel A, Pérez-García M Teresa, López-López José R

Abstract excerpt

The voltage-dependent potassium channel Kv1.3 has been implicated in proliferation in many cell types, based on the observation that Kv1.3 blockers inhibited proliferation. By modulating membrane potential, cell volume, and/or Ca2+ influx, K+ channels can influence cell cycle progression. Also, noncanonical channel functions could contribute to modulate cell proliferation independent of K+ efflux. The...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33230847
DOI: 10.1002/jcp.30170

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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