Article
Amino acid signaling to mTOR mediated by inositol polyphosphate multikinase.
Cell metabolism - 2 Feb 2011
Kim Seyun, Kim Sangwon F, Maag David, Maxwell Micah J, Resnick Adam C, Juluri Krishna R, Chakraborty Anutosh, Koldobskiy Michael A, Cha Seung Hun, Barrow Roxanne, Snowman Adele M, Snyder Solomon H
Abstract excerpt
mTOR complex 1 (mTORC1; mammalian target of rapamycin [mTOR] in complex with raptor) is a key regulator of protein synthesis and cell growth in response to nutrient amino acids. Here we report that inositol polyphosphate multikinase (IPMK), which possesses both inositol phosphate kinase and lipid kinase activities, regulates amino acid signaling to mTORC1. This regulation is independent of IPMK's catalytic...
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