Article
Variation in eicosanoid genes, non-fatal myocardial infarction and ischemic stroke.
Atherosclerosis - 1 Jun 2009
Lemaitre Rozenn N, Rice Kenneth, Marciante Kristin, Bis Joshua C, Lumley Thomas S, Wiggins Kerri L, Smith Nicholas L, Heckbert Susan R, Psaty Bruce M
Abstract excerpt
OBJECTIVES: Eicosanoids are lipid mediators that may play a role in atherosclerosis. We investigated the association of common genetic variation in prostaglandin H synthase 1 (PTGS1), prostaglandin H synthase 2 (PTGS2), thromboxane A2 synthase (TBXAS1), prostacyclin synthase (PTGIS), prostaglandin E synthase (PTGES), 5-lipoxygenase activating protein (ALOX5AP), 12-lipoxygenase (ALOX12) and 15-lipoxygenase...
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