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Article

CYP2J2 and CYP2C8 polymorphisms and coronary heart disease risk: the Atherosclerosis Risk in Communities (ARIC) study.

Pharmacogenetics and genomics - 1 May 2007

Lee Craig R, North Kari E, Bray Molly S, Couper David J, Heiss Gerardo, Zeldin Darryl C

Abstract excerpt

OBJECTIVE: The cytochromes P450 epoxygenases CYP2J2 and CYP2C8 synthesize epoxyeicosatrienoic acids, which regulate endothelial function. We sought to determine if genetic variation in CYP2J2 and CYP2C8 was associated with coronary heart disease risk. METHODS: We genotyped 2065 Atherosclerosis Risk in Communities study participants (1085 incident coronary heart disease cases, 980 noncases) for polymorphisms in...

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Identifiers

PMID: 17429317
DOI: 10.1097/FPC.0b013e32809913ea
PMCID: PMC1947003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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