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Article

Prediction of sites under adaptive evolution in cytochrome P450 sequences and their relationship to substrate recognition sites.

Pharmacogenetics and genomics - 1 Jun 2008

Zawaira Alexander, Matimba Alice, Masimirembwa Collen

Abstract excerpt

We have used maximum-likelihood models of codon substitution to investigate the role of adaptive evolution in the evolution of cytochrome P450 (CYP) sequences. Evidence for the operation of adaptive evolution in the evolution of rat CYP2C, rabbit CYP2C, rat CYP2D, human CYP3A and rabbit CYP4A was observed. The absence of signal in rat CYP2B, rat CYP3A, human CYP2C and monkey CYP2C suggests that the adaptive...

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PMID: 18496126
DOI: 10.1097/FPC.0b013e3282f9b68e

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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