Substrate recognition sites in cytochrome P450 family 2 (CYP2) proteins inferred from comparative analyses of amino acid and coding nucleotide sequences.

Article

Substrate recognition sites in cytochrome P450 family 2 (CYP2) proteins inferred from comparative analyses of amino acid and coding nucleotide sequences.

The Journal of biological chemistry - 5 Jan 1992

Gotoh O

Abstract excerpt

The substrate recognition regions in cytochrome P450 family 2 (CYP2) proteins were inferred by group-to-group alignment of CYP2 sequences and those of bacterial P450s, including Pseudomonas putida P450 101A (P450cam), whose substrate-binding residues have been definitely identified by x-ray cryst...

Topics

Amino Acid Sequence
Animals
Base Sequence
Cytochrome P-450 Enzyme System
Humans
Molecular Sequence Data
Mutation
Protein Conformation
Sequence Alignment
Substrate Specificity
X-Ray Diffraction

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