Article
Cytochrome P450 1 genes in early deuterostomes (tunicates and sea urchins) and vertebrates (chicken and frog): origin and diversification of the CYP1 gene family.
Molecular biology and evolution - 1 Dec 2007
Goldstone Jared V, Goldstone Heather M H, Morrison Ann M, Tarrant Ann, Kern Suzanne E, Woodin Bruce R, Stegeman John J
Abstract excerpt
Cytochrome P450 family 1 (CYP1) proteins are important in a large number of toxicological processes. CYP1A and CYP1B genes are well known in mammals, but the evolutionary history of the CYP1 family as a whole is obscure; that history may provide insight into endogenous functions of CYP1 enzymes. Here, we identify CYP1-like genes in early deuterostomes (tunicates and echinoderms), and several new CYP1 genes in...
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