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Article

Essential requirements for substrate binding affinity and selectivity toward human CYP2 family enzymes.

Archives of biochemistry and biophysics - 1 Jan 2003

Lewis David F V

Abstract excerpt

A detailed analysis of substrate selectivity within the cytochrome P450 2 (CYP2) family is reported. From a consideration of specific interactions between drug substrates for human CYP2 family enzymes and the putative active sites of CYP2A6, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, and CYP2E1, it is likely that the number and disposition of hydrogen bond donor/acceptors and aromatic rings within the various P450...

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Identifiers

PMID: 12464242
DOI: 10.1016/s0003-9861(02)00349-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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