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Article

Role of cytochrome P450 2B sequence variation and gene copy number in facilitating dietary specialization in mammalian herbivores.

Molecular ecology - 1 Feb 2018

Kitanovic Smiljka, Orr Teri J, Spalink Daniel, Cocke Granger B, Schramm Katharina, Wilderman P Ross, Halpert James R, Dearing M Denise

Abstract excerpt

Theory postulates that dietary specialization in mammalian herbivores is enabled by a specialized set of liver enzymes that process the high concentrations of similar plant secondary metabolites (PSMs) in the diets of specialists. To investigate whether qualitative and quantitative differences in detoxification mechanisms distinguish dietary specialists from generalists, we compared the sequence diversity and...

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PMID: 29319892
DOI: 10.1111/mec.14480

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