Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phylogenetic and functional analysis of the vertebrate cytochrome p450 2 family.

Journal of molecular evolution - 1 Jan 2011

Kirischian Nina, McArthur Andrew G, Jesuthasan Caroline, Krattenmacher Birgit, Wilson Joanna Y

Abstract excerpt

Cytochrome P450 (CYP) proteins compose a highly diverse superfamily found in all domains of life. These proteins are enzymes involved in metabolism of endogenous and exogenous compounds. In vertebrates, the CYP2 family is one of the largest, most diverse and plays an important role in mammalian drug metabolism. However, there are more than 20 vertebrate CYP2 subfamilies with uncertain evolution and fairly...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bayes Theorem
Share to Cattle
Share to Cytochrome P-450 Enzyme System

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome

Share to Multigene Family

Share to Rabbits

Share to Vertebrates

Source

Identifiers

PMID: 21116621
DOI: 10.1007/s00239-010-9402-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phylogenetic and functional analysis of the vertebrate cytochrome p450 2 family.PMID 21116621Read ↗

Cytochrome P450 1 genes in early deuterostomes (tunicates and sea urchins) and vertebrates (chicken and frog): origin and diversification of the CYP1 gene family.Semantic proximity Read ↗

Isolation and characterization of the CYP2D6 gene in Felidae with comparison to other mammals.Semantic proximity Read ↗

Structure, function, regulation and polymorphism and the clinical significance of human cytochrome P450 1A2.Semantic proximity Read ↗

Diversity and distribution of CYP gene family in Bactrian camel.Semantic proximity Read ↗

Molecular evolution of the CYP2D subfamily in primates: purifying selection on substrate recognition sites without the frequent or long-tract gene conversion.Semantic proximity Read ↗

Structure of cytochrome p450s and personalized drug.Semantic proximity Read ↗

Cytochrome P450 2U1, a very peculiar member of the human P450s family.Semantic proximity Read ↗

Insect Cytochrome P450 Database: an integrated resource of genetic diversity, evolution and functionSemantic proximity Read ↗

Prediction of sites under adaptive evolution in cytochrome P450 sequences and their relationship to substrate recognition sites.Semantic proximity Read ↗

Substrate recognition sites in cytochrome P450 family 2 (CYP2) proteins inferred from comparative analyses of amino acid and coding nucleotide sequences.Semantic proximity Read ↗

CpG site degeneration triggered by the loss of functional constraint created a highly polymorphic macaque drug-metabolizing gene, CYP1A2.Semantic proximity Read ↗

The CYP2A gene subfamily: species differences, regulation, catalytic activities and role in chemical carcinogenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.