Analysis of the catalytic specificity of cytochrome P450 enzymes through site-directed mutagenesis.

doi:10.1096/fasebj.6.2.1537459

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Article

Analysis of the catalytic specificity of cytochrome P450 enzymes through site-directed mutagenesis.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 6 Jan 1992

Johnson E F, Kronbach T, Hsu M H

Abstract excerpt

The way in which structural diversity encodes the capacity of individual P450 enzymes to metabolize multiple, structurally distinct substrates remains largely unknown. The tools of molecular biology provide a means of identifying amino acid residues among closely related P450s that are determinan...

Topics

Amino Acid Sequence
Animals
Cytochrome P-450 Enzyme System
Genetic Variation
Molecular Sequence Data
Mutagenesis, Site-Directed
RNA Splicing
Sequence Homology, Nucleic Acid
Steroid 21-Hydroxylase

Source

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Identifiers

PMID: 1537459
DOI: 10.1096/fasebj.6.2.1537459

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1537459-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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