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Article

Analysis of the catalytic specificity of cytochrome P450 enzymes through site-directed mutagenesis.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 6 Jan 1992

Johnson E F, Kronbach T, Hsu M H

Abstract excerpt

The way in which structural diversity encodes the capacity of individual P450 enzymes to metabolize multiple, structurally distinct substrates remains largely unknown. The tools of molecular biology provide a means of identifying amino acid residues among closely related P450s that are determinants of their distinct catalytic properties. Work in our laboratory has identified two substrate specificity-determining...

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Share to Amino Acid Sequence
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Sequence Homology, Nucleic Acid

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Source

Identifiers

PMID: 1537459
DOI: 10.1096/fasebj.6.2.1537459

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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