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Article

CpG site degeneration triggered by the loss of functional constraint created a highly polymorphic macaque drug-metabolizing gene, CYP1A2.

BMC evolutionary biology - 1 Oct 2011

Uno Yasuhiro, Osada Naoki

Abstract excerpt

BACKGROUND: Elucidating the pattern of evolutionary changes in drug-metabolizing genes is an important subject not only for evolutionary but for biomedical research. We investigated the pattern of divergence and polymorphisms of macaque CYP1A1 and CYP1A2 genes, which are major drug-metabolizing genes in humans. In humans, CYP1A2 is specifically expressed in livers while CYP1A1 has a wider gene expression pattern...

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Identifiers

PMID: 21961956
DOI: 10.1186/1471-2148-11-283
PMCID: PMC3199271

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