Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

B-lineage commitment prior to surface expression of B220 and CD19 on hematopoietic progenitor cells

21 May 2008

Abstract excerpt

Commitment of hematopoietic progenitor cells to B-lymphoid cell fate has been suggested to coincide with the development of PAX5-expressing B220(+)CD19(+) pro-B cells. We have used a transgenic reporter mouse, expressing human CD25 under the control of the B-lineage-restricted Igll1 (lambda5) promoter to investigate the lineage potential of early progenitor cells in the bone marrow. This strategy allowed us to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hematopoietic Stem Cell Transplantation
Share to Immune Cell Function and Interaction
Share to T-cell and B-cell Immunology

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18495958
DOI: 10.1182/blood-2007-11-125385

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

B-lineage commitment prior to surface expression of B220 and CD19 on hematopoietic progenitor cellsPMID 18495958Read ↗

B Cell Development PathwaysSemantic proximity Read ↗

Biphenotypic B-lymphoid/myeloid cells expressing low levels of Pax5: potential targets of BAL development.Semantic proximity Read ↗

B-1 B cell progenitors transiently and partially express keratin 5 during differentiation in bone marrow.Semantic proximity Read ↗

Identification of the earliest B lineage stage in mouse bone marrow.Semantic proximity Read ↗

The molecular basis of B-cell lineage commitment.Semantic proximity Read ↗

Dysregulation of PAX5 causes uncommitted B cell development and tumorigenesis in miceSemantic proximity Read ↗

Tracing lymphopoiesis with the aid of a pTalpha-controlled reporter gene.Semantic proximity Read ↗

Induction of chemokine receptor expression during early stages of T cell development.Semantic proximity Read ↗

Lineage commitment in lymphopoiesis.Semantic proximity Read ↗

Transcription from the RAG1 locus marks the earliest lymphocyte progenitors in bone marrow.Semantic proximity Read ↗

Pax5/BSAP maintains the identity of B cells in late B lymphopoiesis.Semantic proximity Read ↗

Combined heterozygous loss of Ebf1 and Pax5 allows for T-lineage conversion of B cell progenitors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.