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Article

Transcription from the RAG1 locus marks the earliest lymphocyte progenitors in bone marrow.

Immunity - 1 Aug 2002

Igarashi Hideya, Gregory Sophia C, Yokota Takafumi, Sakaguchi Nobuo, Kincade Paul W

Abstract excerpt

Viable Lin(-) CD27(+) c-kit(Hi) Sca-1(Hi) GFP(+) cells recovered from heterozygous RAG1/GFP knockin mice progressed through previously defined stages of B, T, and NK cell lineage differentiation. In contrast to the GFP(-) cohort, there was minimal myeloid or erythroid potential in cells with an active RAG1 locus. Partial overlap with TdT(+) cells suggested that distinctive early lymphocyte characteristics are not...

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Source

Identifiers

PMID: 12196284
DOI: 10.1016/s1074-7613(02)00366-7

Genes

RAG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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