Article
Induction of chemokine receptor expression during early stages of T cell development.
Immunology letters - 15 Apr 2006
Maerki Sarah, Ceredig Rod, Rolink Antonius
Abstract excerpt
The early events in T lineage commitment are difficult to study because of the rarity of these cells. We have therefore used cloned Pax5-/- pre-BI cell lines as a model system to study this. Stimulation in vitro of Pax5-/- pre-BI cells with stromal cells expressing the Notch ligand Delta-like 1 results in them coincidently undergoing some of the phenotypic and functional changes associated with early T cell...
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