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Article

The glycogen synthase kinase (GSK) 3beta represses RNA polymerase I transcription.

Oncogene - 4 Sept 2008

Vincent T, Kukalev A, Andäng M, Pettersson R, Percipalle P

Abstract excerpt

Several oncogenic proteins and tumour suppressors target the RNA polymerase I and interfere with rRNA synthesis. Here, we show that the glycogen synthase kinase (GSK) 3beta, which phosphorylates the tumour suppressor PTEN (phosphatase and tensin homologue deleted on chromosome 10), is selectively enriched in nucleoli of RAS-transformed cells. Immunoprecipitation and chromatin immunoprecipitation assays performed...

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Source

Identifiers

PMID: 18490923
DOI: 10.1038/onc.2008.152

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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