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Article

Glycogen synthase kinase-3 and alternative splicing.

Wiley interdisciplinary reviews. RNA - 1 Nov 2018

Liu Xiaolei, Klein Peter S

Abstract excerpt

Glycogen synthase kinase-3 (GSK-3) is a highly conserved negative regulator of receptor tyrosine kinase, cytokine, and Wnt signaling pathways. Stimulation of these pathways inhibits GSK-3 to modulate diverse downstream effectors that include transcription factors, nutrient sensors, glycogen synthesis, mitochondrial function, circadian rhythm, and cell fate. GSK-3 also regulates alternative splicing in response to...

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Source

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Identifiers

PMID: 30118183
DOI: 10.1002/wrna.1501
PMCID: PMC6185797

Genes

NPM1
PHF6
SRSF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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