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Article

PTEN Represses RNA Polymerase I Transcription by Disrupting the SL1 Complex

29 Jul 2005

Abstract excerpt

PTEN is a tumor suppressor whose function is frequently lost in human cancer. It possesses a lipid phosphatase activity that represses the activation of PI3 kinase/Akt signaling, leading to decreased cell growth, proliferation, and survival. The potential for PTEN to regulate transcription of the large rRNAs by RNA polymerase I (RNA Pol I) was investigated. As increased synthesis of rRNAs is a hallmark of...

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PMID: 16055704
DOI: 10.1128/mcb.25.16.6899-6911.2005

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PTEN Represses RNA Polymerase I Transcription by Disrupting the SL1 ComplexPMID 16055704Read ↗

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Polo-like Kinase 1 Facilitates Loss of Pten Tumor Suppressor-induced Prostate Cancer FormationSemantic proximity Read ↗

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Nuclear PTEN-mediated growth suppression is independent of Akt down-regulation.Semantic proximity Read ↗

Phosphatase of regenerating liver 2 (PRL2) is essential for placental development by down-regulating PTEN (Phosphatase and Tensin Homologue Deleted on Chromosome 10) and activating Akt protein.Semantic proximity Read ↗

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Cell cycle arrest by the PTEN tumor suppressor is target cell specific and may require protein phosphatase activity.Semantic proximity Read ↗

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