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Article

Dynamic Telomerase Gene Suppression via Network Effects of GSK3 Inhibition

30 Jul 2009

Abstract excerpt

BACKGROUND: Telomerase controls telomere homeostasis and cell immortality and is a promising anti-cancer target, but few small molecule telomerase inhibitors have been developed. Reactivated transcription of the catalytic subunit hTERT in cancer cells controls telomerase expression. Better understanding of upstream pathways is critical for effective anti-telomerase therapeutics and may reveal new targets to...

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Share to Genomics and Chromatin Dynamics
Share to Telomeres, Telomerase, and Senescence
Share to Wnt/β-catenin signaling in development and cancer

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PMID: 19649288
DOI: 10.1371/journal.pone.0006459

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