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PTENβ is an alternatively translated isoform of PTEN that regulates rDNA transcription

23 Mar 2017

Abstract excerpt

PTEN is a critical tumour suppressor that is frequently mutated in human cancer. We have previously identified a CUG initiated PTEN isoform designated PTENα, which functions in mitochondrial bioenergetics. Here we report the identification of another N-terminal extended PTEN isoform, designated PTENβ. PTENβ translation is initiated from an AUU codon upstream of and in-frame with the AUG initiation sequence for...

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PMID: 28332494
DOI: 10.1038/ncomms14771

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