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Article

Mutant K-Ras increases GSK-3β gene expression via an ETS-p300 transcriptional complex in pancreatic cancer.

Oncogene - 25 Aug 2011

Zhang J-S, Koenig A, Harrison A, Ugolkov A V, Fernandez-Zapico M E, Couch F J, Billadeau D D

Abstract excerpt

Glycogen synthase kinase-3 beta (GSK-3β) is overexpressed in a number of human malignancies and has been shown to contribute to tumor cell proliferation and survival. Although regulation of GSK-3β activity has been extensively studied, the mechanisms governing GSK-3β gene expression are still unknown. Using pancreatic cancer as a model, we find that constitutively active Ras signaling increases GSK-3β gene...

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Source

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Identifiers

PMID: 21441955
DOI: 10.1038/onc.2011.90
PMCID: PMC3162070

Genes

ETS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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