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Tumor Suppressor WWOX inhibits osteosarcoma metastasis by modulating RUNX2 function

10 Aug 2015

Abstract excerpt

Osteosarcoma (OS) is among the most frequently occurring primary bone tumors, primarily affecting adolescents and young adults. This malignant osteoid forming tumor is characterized by its metastatic potential, mainly to lungs. We recently demonstrated that WW domain-containing oxidoreductase (WWOX) is frequently inactivated in human OS and that WWOX restoration in WWOX-negative OS cells suppresses...

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PMID: 26256646
DOI: 10.1038/srep12959

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