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Article

A murine model to characterize the antithrombotic effect of molecules targeting human von Willebrand factor.

Blood - 27 Sept 2012

Navarrete Ana-Maria, Casari Caterina, Legendre Paulette, Marx Isabelle, Hu Jiun-Ruey, Lenting Peter J, Christophe Olivier D, Denis Cécile V

Abstract excerpt

von Willebrand factor (VWF) is a promising target for developing antithrombotic drugs. The absence of accessible animal models impedes the study of specific human VWF (huVWF) targeting molecules in thrombosis. huVWF is not functional in the mouse because of a lack of interaction between huVWF and murine glycoprotein Ib. Using site-directed mutagenesis, we have replaced single or multiple amino acids in huVWF with...

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Identifiers

PMID: 22915646
DOI: 10.1182/blood-2012-03-420042

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VWF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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