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Article

Absence of gene mutations in KIT-positive thymic epithelial tumors.

Lung cancer (Amsterdam, Netherlands) - 1 Dec 2008

Tsuchida Masanori, Umezu Hajime, Hashimoto Takehisa, Shinohara Hirohiko, Koike Terumoto, Hosaka Yasuko, Eimoto Tadaaki, Hayashi Jun-ich

Abstract excerpt

BACKGROUND: Overexpression of KIT, a tyrosine kinase receptor protein encoded by the proto-oncogene c-kit, is observed in human neoplasms such as gastrointestinal stromal tumors (GISTs), myeloproliferative disorders, melanoma and seminoma. In patients with GIST, overexpression of mutated KIT within the tumor is predictive of response to molecular targeted therapy using imatinib. However, the role of KIT...

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Source

Identifiers

PMID: 18486988
DOI: 10.1016/j.lungcan.2008.03.035

Genes

KIT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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