Article
Expression and mutational status of c-kit in thymic epithelial tumors.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Sept 2010
Petrini Iacopo, Zucali Paolo A, Lee Hye Seung, Pineda Marbin A, Meltzer Paul S, Walter-Rodriguez Beatriz, Roncalli Massimo, Santoro Armando, Wang Yisong, Giaccone Giuseppe
Abstract excerpt
BACKGROUND: Overexpression of c-kit, a tyrosine kinase receptor protein encoded by the protooncogene kit, has been previously reported in thymic epithelial tumors and in other neoplasms such as gastrointestinal stromal tumors, myeloproliferative disorders, melanoma, and seminoma. Mutations in the kit gene have been related to response to imatinib in gastrointestinal stromal tumor and one case report of thymic...
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