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Article

Molecular Profiling of Thymoma and Thymic Carcinoma: Genetic Differences and Potential Novel Therapeutic Targets.

Pathology oncology research : POR - 1 Jul 2017

Enkner Franz, Pichlhöfer Bettina, Zaharie Alexandru Teodor, Krunic Milica, Holper Tina Maria, Janik Stefan, Moser Bernhard, Schlangen Karin, Neudert Barbara, Walter Karin, Migschitz Brigitte, Müllauer Leonhard

Abstract excerpt

Thymoma and thymic carcinoma are thymic epithelial tumors (TETs). We performed a molecular profiling to investigate the pathogenesis of TETs and identify novel targets for therapy. We analyzed 37 thymomas (18 type A, 19 type B3) and 35 thymic carcinomas. The sequencing of 50 genes detected nonsynonymous mutations in 16 carcinomas affecting ALK, ATM, CDKN2A, ERBB4, FGFR3, KIT, NRAS and TP53. Only two B3 thymomas...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27844328
DOI: 10.1007/s12253-016-0144-8
PMCID: PMC5487866

Genes

ALK
ATM
PDGFRA
ERBB4
FGFR3
HRAS
KIT
MET
NRAS
PDGFRB
PTEN
ROS1
SMARCB1
STK11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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