Article
Apparent bypass of negative selection in CD8+ tumours in CD2-myc transgenic mice.
British journal of cancer - 1 Jan 1996
Cameron E R, Campbell M, Blyth K, Argyle S A, Keanie L, Neil J C, Onions D E
Abstract excerpt
A role for antigen stimulation in lymphoid neoplasia has been postulated and is supported by indirect evidence that suggests that the interaction of antigen with both T cells and B cells may constitute an epigenetic event that can contribute to tumour induction or tumour progression. Using myc-be...
Topics
- Animals
- CD2 Antigens
- CD4-CD8 Ratio
- CD4-Positive T-Lymphocytes
- CD8-Positive T-Lymphocytes
- Cell Transformation, Neoplastic
- Genes, myc
- Lymphoma, T-Cell
- Mice
- Mice, Inbred C57BL
- Mice, Inbred CBA
- Mice, Transgenic
- Phenotype
- Receptors, Antigen, T-Cell, alpha-beta
- Superantigens