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Article

Apparent bypass of negative selection in CD8+ tumours in CD2-myc transgenic mice.

British journal of cancer - 1 Jan 1996

Cameron E R, Campbell M, Blyth K, Argyle S A, Keanie L, Neil J C, Onions D E

Abstract excerpt

A role for antigen stimulation in lymphoid neoplasia has been postulated and is supported by indirect evidence that suggests that the interaction of antigen with both T cells and B cells may constitute an epigenetic event that can contribute to tumour induction or tumour progression. Using myc-bearing transgenic mice that develop mainly clonal T-cell lymphomas we have investigated the possibility that endogenous...

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Identifiers

PMID: 8554976
DOI: 10.1038/bjc.1996.3
PMCID: PMC2074291

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Apparent bypass of negative selection in CD8+ tumours in CD2-myc transgenic mice.PMID 8554976Read ↗

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Cooperative action of CD8 T lymphocytes and natural killer cells controls tumour growth under conditions of restricted T‐cell receptor diversitySemantic proximity Read ↗

CD2 regulates the positive selection and function of antigen-specific CD4- CD8+ T cells.Semantic proximity Read ↗

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