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Article

Mutagenic roles of DNA "repair" proteins in antibody diversity and disease-associated trinucleotide repeat instability.

DNA repair - 1 Jul 2008

Slean Meghan M, Panigrahi Gagan B, Ranum Laura P, Pearson Christopher E

Abstract excerpt

While DNA repair proteins are generally thought to maintain the integrity of the whole genome by correctly repairing mutagenic DNA intermediates, there are cases where DNA "repair" proteins are involved in causing mutations instead. For instance, somatic hypermutation (SHM) and class switch recombination (CSR) require the contribution of various DNA repair proteins, including UNG, MSH2 and MSH6 to mutate certain...

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Topics

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Share to Antibody Diversity
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunoglobulin Class Switching

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Share to Somatic Hypermutation, Immunoglobulin

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Source

Identifiers

PMID: 18485833
DOI: 10.1016/j.dnarep.2008.03.014

Genes

TNR
MSH2
MSH6
UNG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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