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DNA Mismatch Repair and its Role in Huntington’s Disease

9 Feb 2021

Abstract excerpt

DNA mismatch repair (MMR) is a highly conserved genome stabilizing pathway that corrects DNA replication errors, limits chromosomal rearrangements, and mediates the cellular response to many types of DNA damage. Counterintuitively, MMR is also involved in the generation of mutations, as evidenced by its role in causing somatic triplet repeat expansion in Huntington's disease (HD) and other neurodegenerative...

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PMID: 33579865
DOI: 10.3233/jhd-200438

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