Article
Interphase microtubule bundles use global cell shape to guide spindle alignment in fission yeast.
Journal of cell science - 15 Jun 2008
Daga Rafael R, Nurse Paul
Abstract excerpt
Correct spindle alignment requires a cell to detect and interpret its global geometry and to communicate this information to the mitotic spindle. In the fission yeast, Schizosaccharomyces pombe, the mitotic spindle is aligned with the longitudinal axis of the rod-shaped cell. Here, using wild-type and cell-shape mutants we investigate the mechanism of initial spindle alignment and show that attachment of...
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