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Article

Truncation in CCND1 mRNA alters miR-16-1 regulation in mantle cell lymphoma.

Blood - 1 Aug 2008

Chen Robert W, Bemis Lynne T, Amato Carol M, Myint Han, Tran Hung, Birks Diane K, Eckhardt S Gail, Robinson William A

Abstract excerpt

Cyclin D1 (CCND1) is a well-known regulator of cell-cycle progression. It is overexpressed in several types of cancer including breast, lung, squamous, neuroblastoma, and lymphomas. The most well-known mechanism of overexpression is the t(11;14)(q13;q32) translocation found in mantle cell lymphoma (MCL). It has previously been shown that truncated CCND1 mRNA in MCL correlates with poor prognosis. We hypothesized...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18483394
DOI: 10.1182/blood-2008-03-142182
PMCID: PMC2481543

Genes

CCND1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Truncation in CCND1 mRNA alters miR-16-1 regulation in mantle cell lymphoma.PMID 18483394Read ↗

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The impact of cyclin D1 mRNA isoforms, morphology and p53 in mantle cell lymphoma: p53 alterations and blastoid morphology are strong predictors of a high proliferation index.Semantic proximity Read ↗

Rearrangement of CCND1 (BCL1/PRAD1) 3' untranslated region in mantle- cell lymphomas and t(11q13)-associated leukemiasSemantic proximity Read ↗

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t(11;14)-positive mantle cell lymphomas lacking cyclin D1 (CCND1) immunostaining because of a CCND1 mutation or exclusive expression of the CCND1b isoform.Semantic proximity Read ↗

Translocations targeting CCND2, CCND3, and MYCN do occur in t(11;14)-negative mantle cell lymphomas.Semantic proximity Read ↗

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