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Article

Cyclin D1-negative mantle cell lymphoma: a clinicopathologic study based on gene expression profiling

25 Aug 2005

Abstract excerpt

Cyclin D1 overexpression is believed to be essential in the pathogenesis of mantle cell lymphoma (MCL). Hence, the existence of cyclin D1-negative MCL has been controversial and difficult to substantiate. Our previous gene expression profiling study identified several cases that lacked cyclin D1 expression, but had a gene expression signature typical of MCL. Herein, we report the clinical, pathologic, and genetic...

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PMID: 16123218
DOI: 10.1182/blood-2005-04-1753

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