Article
CCND1 mutations increase protein stability and promote ibrutinib resistance in mantle cell lymphoma.
Oncotarget - 8 Nov 2016
Mohanty Atish, Sandoval Natalie, Das Manasi, Pillai Raju, Chen Lu, Chen Robert W, Amin Hesham M, Wang Michael, Marcucci Guido, Weisenburger Dennis D, Rosen Steven T, Pham Lan V, Ngo Vu N
Abstract excerpt
Mantle cell lymphoma (MCL) is characterized by the t(11;14) translocation, which leads to deregulated expression of the cell cycle regulatory protein cyclin D1 (CCND1). Genomic studies of MCL have also identified recurrent mutations in the coding region of CCND1. However, the functional consequence of these mutations is not known. Here, we showed that, compared to wild type (WT), single E36K, Y44D or C47S CCND1...
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