Article
The impact of cyclin D1 mRNA isoforms, morphology and p53 in mantle cell lymphoma: p53 alterations and blastoid morphology are strong predictors of a high proliferation index.
Haematologica - 1 Sept 2012
Slotta-Huspenina Julia, Koch Ina, de Leval Laurence, Keller Gisela, Klier Margit, Bink Karin, Kremer Marcus, Raffeld Mark, Fend Falko, Quintanilla-Martinez Leticia
Abstract excerpt
BACKGROUND: Mantle cell lymphoma is a clinically heterogeneous disease characterized by overexpression of cyclin D1 protein. Blastoid morphology, high proliferation, and secondary genetic aberrations are markers of aggressive behavior. Expression profiling of mantle cell lymphoma revealed that predominance of the 3'UTR-deficient, short cyclin D1 mRNA isoform was associated with high cyclin D1 levels, a high...
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