Functional polymorphisms in folate metabolism genes influence the risk of meningioma and glioma.

doi:10.1158/1055-9965.EPI-07-2733

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Article

Functional polymorphisms in folate metabolism genes influence the risk of meningioma and glioma.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 May 2008

Bethke Lara, Webb Emily, Murray Anne, Schoemaker Minouk, Feychting Maria, Lönn Stefan, Ahlbom Anders, Malmer Beatrice, Henriksson Roger, Auvinen Anssi, Kiuru Anne, Salminen Tiina, Johansen Christoffer, Christensen Helle Collatz, Muir Kenneth, McKinney Patricia, Hepworth Sarah, Dimitropoulou Polyxeni, Lophatananon Artitaya, Swerdlow Anthony, Houlston Richard

Abstract excerpt

Folate metabolism plays an important role in carcinogenesis. To test the hypothesis that polymorphic variation in the folate metabolism genes 5,10-methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTRR), and methionine synthase reductase (MTR) influences the risk of primary brain tumors, we genotyped 1,005 glioma cases, 631 meningioma cases, and 1,101 controls for the MTHFR C677A and A1298C, MTRR...

Topics

5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
Brain Neoplasms
Case-Control Studies
Female
Ferredoxin-NADP Reductase
Folic Acid
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genotype

Glioma

Humans

Male

Meningeal Neoplasms

Meningioma

Methylenetetrahydrofolate Dehydrogenase (NADP)

Methylenetetrahydrofolate Reductase (NADPH2)

Middle Aged

Polymorphism, Single Nucleotide

Risk

Source

Open in PubMed

Identifiers

PMID: 18483342
DOI: 10.1158/1055-9965.EPI-07-2733

Genes

MTHFR
MTRR
MTR

Variants

Provenance

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