C677T gene polymorphism of methylenetetrahydrofolate reductase (MTHFR) in meningiomas and high-grade gliomas.

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

C677T gene polymorphism of methylenetetrahydrofolate reductase (MTHFR) in meningiomas and high-grade gliomas.

Anticancer research - 1 Jan 2000

Kafadar Ali Metin, Yilmaz Hulya, Kafadar Didem, Ergen Arzu, Zeybek Umit, Bozkurt Nilufer, Kuday Cengiz, Isbir Turgay

Abstract excerpt

BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) plays a role in DNA biosynthesis, methylation and repair in actively dividing cells by acting on folate metabolism. A common C677T polymorphism in the gene for MTHFR leads to an enzyme with decreased activity. MTHFR polymorphisms have been s...

Topics

Alleles
Brain Neoplasms
Case-Control Studies
Female
Genotype
Glioma
Humans
Male
Meningeal Neoplasms
Meningioma
Methylenetetrahydrofolate Reductase (NADPH2)
Middle Aged
Polymorphism, Genetic
Prospective Studies

Source

Open in PubMed

Identifiers

PMID: 16821630

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-16821630-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics