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Article

C677T gene polymorphism of methylenetetrahydrofolate reductase (MTHFR) in meningiomas and high-grade gliomas.

Anticancer research - 1 Jan 2000

Kafadar Ali Metin, Yilmaz Hulya, Kafadar Didem, Ergen Arzu, Zeybek Umit, Bozkurt Nilufer, Kuday Cengiz, Isbir Turgay

Abstract excerpt

BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) plays a role in DNA biosynthesis, methylation and repair in actively dividing cells by acting on folate metabolism. A common C677T polymorphism in the gene for MTHFR leads to an enzyme with decreased activity. MTHFR polymorphisms have been studied in various cancers but not in primary brain tumors. The purpose of this case-control study was to explore a...

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Source

Identifiers

PMID: 16821630

Genes

MTHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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